Androgen deficiency in the aging male (ADAM), also known as andropause, affects an estimated 1 in 200 men. Symptoms of testosterone deficiency may include:

• weakness
• fatigue
• reduced libido
• osteoporosis

A man may be considered hypogonadal at any age if total testosterone is less than 200 ng/dl, or bioavailable testosterone is less than 60 ng/dl. Basaria and Dobs of Johns Hopkins University recommend that elderly men with symptoms of hypogonadism and a total testosterone level < 300ng/dl should be started on hormone replacement.